TheraGlio - developing theranostics for gliomas.

Seroscience Kutato Fejleszto Es Kereskedelmi
Korlatolt Felelossegu Tarsasag - Seroscience Ltd.
seroscience@theraglio.eu

Seroscience Kutato Fejleszto Es Kereskedelmi Korlatolt Felelossegu Tarsasag (Seroscience Ltd) is a spin-off SME of Semmelweis University, in Budapest, Hungary. It is a contract research organization providing immune toxicology services to pharmaceutical companies. Its special expertise is nanoimmune toxicology, in particular, the adverse effects of nanoparticle-induced complement activation and related cardiovascular changes. It has negotiated with Semmelweis University full access to university laboratory spaces, research equipment and a separate dedicated facility for animal toxicology studies. Scientists in the company are also involved in internationally recognized, state-of-art research on complement activation-related adverse immune effects. The company has got numerous grants for participating in domestic and FP7 consortial research.

Main tasks attributed to the organisation: Carry out acute and chronic toxicity, immunogenicity profiling for functionalized MBs developed in the project SeroScience Ltd will conduct 1) standard toxicity assays for membrane integrity and cell death in cell cultures in vitro (endothelial, neuronal, liver, kidney cell lines) for the lipidic and polymeric microbubbles; 2) biocompatibility and immune reactivity studies testing complement activation, thrombosis, coagulation, platelet activation, leukocyte function in vitro; 3) complement activation related pseudoallergy and immunogenicity studies in vivo in various animal models including large animals (pigs and/or dogs).